You can change an adult diaper while the person is lying down or while they are sitting on a toilet. Remember, you should always change the diaper as soon as it is soiled. Youth and Adult Diapers. It's important to have clean hands before starting, as you don't want to bring your germs to the patient. You should also wear disposable latex gloves or vinyl if you are allergic or if your patient is allergic to latex to protect your hands against bodily fluids.